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lytic lesions myelomatreatment of metastatic melanomalymphoma metastaticmetastatic mesotheliomapulmonary metastatic diseasemalignant melanoma metastatichepatic metastatic diseasemetastatic hepatocellular carcinomaprognosis metastatic melanomametastatic papillary carcinomametastatic pancreatic carcinomametastatic ocular melanoma